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GPI downregulation commits glycolytic intermediates to the PPP rather than glycolysis

PMID: 37366315 | doi:10.1056/NEJMoa2301972 Rosenstock J et al

Following administration in animal models: BPC-157 demonstrates rapid systemic distribution within 15-30 minutes of administration TB-500 shows tissue-specific accumulation with preferential uptake in injured areas GHK-Cu exhibits copper-mediated transport and tissue binding characteristics Combined formulation provides both immediate and sustained bioactivity Distribution studies suggest that while each peptide follows distinct pathways, injury sites tend to concentrate all three components, potentially enhancing local therapeutic effects through multiple mechanisms

Cuando un tejido se daa por una herida, una inflamacin o el estrs oxidativo las protenas de la matriz extracelular (principalmente el colgeno y la SPARC) se degradan, liberando fragmentos peptdicos entre los cuales se encuentra el GHK